Industrial Mixers UK
PerMix Applications
Pharmaceutical manufacturing demands absolute precision. Every stage — from blending active ingredients to milling powders and creating emulsions — requires exacting control over particle size, shear, temperature, and contamination.
In this environment, process equipment is not just a tool — it’s a scientific instrument that determines product quality, safety, and compliance.
PerMix and DP Pulverizers work together to deliver fully integrated solutions for pharmaceutical production. From mixing, blending, emulsifying, drying, and coating to micronizing, pulverizing, and classifying, our systems meet the stringent requirements of GMP, FDA, and EMA regulations while driving performance and yield.
Mixing defines uniformity — ensuring each dose contains exactly the intended active ingredients. Pulverizing defines bioavailability — controlling the surface area and solubility of powders and suspensions.
Together, they underpin every key property of the finished drug product: potency, stability, flowability, and dissolution rate.
PerMix’s precision mixers and DP Pulverizers’ advanced milling systems form the backbone of this process — from lab-scale development to commercial production.
Pharmaceutical production involves dozens of unit operations, many of which depend on controlled mixing and milling. Here’s how PerMix and DP Pulverizers contribute at every stage.
| Process / Unit Operation | Mixing / Pulverizing Role | Challenges in Pharma | PerMix + DP Pulverizers Solution |
|---|---|---|---|
| Powder Blending & Dry Mixing | Achieve perfect homogeneity of APIs, excipients, and fillers | Segregation, static, dust, uniformity of micro-dose | PerMix tumble blenders and ribbon/paddle mixers designed with dead-zone-free geometry and variable shear |
| Granulation (Wet or Binder Addition) | Uniform liquid distribution for consistent granule growth | Moisture control, over-shear, localised agglomerates | PerMix high-shear mixers with moisture sensors, staged wet-out and controlled granulation cycles |
| Wet Milling & Slurry Homogenizing | Deagglomeration and particle size reduction in liquid medium | Shear vs. stability, heat generation, viscosity control | PerMix rotor-stator dispersers integrated with DP Pulverizers’ wet mills for fine particle control |
| High-Shear Mixing / Emulsions / Suspensions | Producing uniform emulsions and stable suspensions | Thermal control, droplet size distribution | PerMix inline homogenizers with temperature control and multi-stage dispersion heads |
| Tablet Coating / Film Coating Prep | Preparing coating suspensions and dispersions | Preventing settling, achieving uniform solids | PerMix low-shear mixers and pre-coat dispersers for viscosity and stability management |
| Final Blending for Compression or Filling | Gentle, dust-free blending of finished formulations | Avoiding segregation, electrostatic buildup | PerMix tumble and double-cone blenders with antistatic finishes and CIP-friendly internals |
| Drying & Solvent Removal | Ensuring uniform moisture and solvent distribution | Hot spots, degradation of actives | PerMix vacuum mixers and dryers with heating/cooling jackets and real-time temperature monitoring |
| Particle Size Reduction / Micronization | Reducing API to precise particle size | Heat, contamination, attrition, dust control | DP Pulverizers’ jet mills and classifier mills achieving sub-micron precision under inert or contained atmosphere |
| Reconstitution / Solution Preparation | Dissolving powders into uniform liquid formulations | Solubility, pH, temperature control | PerMix sanitary mixers with low shear impellers and temperature feedback loops |
| Sterile / Aseptic Mixing | Maintaining sterility during mixing | CIP/SIP validation, crevice-free design | PerMix sanitary mixers with polished 316L internals, SIP capability, and aseptic seals |
Pharmaceutical equipment must achieve far more than mechanical performance — it must prove compliance, reproducibility, and sterility.
These are not optional extras — they are designed into every PerMix and DP Pulverizers system from the ground up.
Our systems can be configured as closed-loop mixing and milling platforms — ensuring minimal product loss, seamless transfer, and contamination-free processing.
PerMix mixers use advanced impeller geometry to control shear profiles, while DP Pulverizers mills manage energy input to prevent heat damage and particle degradation.
Both product lines support construction in 316L, Hastelloy, titanium, or Hardox depending on chemical compatibility and wear resistance.
Automation integrates both mixing and milling units, providing complete batch traceability, data acquisition, and alarm management — essential for GMP validation.
From IQ/OQ documentation to FAT/SAT testing and on-site training, both companies provide full lifecycle validation and global technical service.
Manufacturers who adopt PerMix and DP Pulverizers systems report:
The payoff: better control, higher throughput, and superior quality compliance.
Q: Can PerMix and DP Pulverizers systems be installed in GMP cleanrooms?
A: Yes, all equipment is designed to meet GMP and FDA standards with sanitary finishes and full validation support.
Q: Do your mixers integrate with jet mills or classifier mills?
A: Absolutely. We engineer turnkey systems linking PerMix mixers to DP Pulverizers mills in sealed transfer setups.
Q: What particle size range can you achieve?
A: From coarse granules down to sub-micron powders depending on mill type and application.
Q: How do you ensure sterility?
A: CIP/SIP design, sanitary welds, aseptic seals, and fully polished internals prevent contamination and ensure complete cleaning validation.
Q: Can systems be automated for recipe control and data recording?
A: Yes. PLC/HMI automation with recipe management, torque monitoring, and data logging are standard on request.
Pharmaceutical manufacturing continues to evolve — from traditional solid dose production to biologics, injectables, and advanced delivery systems. PerMix and DP Pulverizers are proud to lead that evolution with innovation, precision, and proven engineering.
Together, we deliver mixing and milling systems designed for purity, repeatability, and compliance — from lab bench to full-scale GMP production.
PerMix & DP Pulverizers — Engineering the Science of Consistency.
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